Discoveries and Data: Specific Conditions

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title_bd_gastro_drugs-8492928

pic_bd_painkillers-4776194Gastroschisis is believed to arise from interrupted blood supply to the developing abdominal wall, so factors influencing blood flow and oxygen stress are an important focus for our investigation. Our findings follow.

OVER-THE-COUNTER MEDICATIONS ELEVATE RISK

bullet-2318947 Mothers taking aspirin or ibuprofen had a 4-5 time higher risk. These medications are strong cyclooxygenase inhibitors, active in pathways that decrease blood flow. Acetaminophen (which works by a different mechanism) showed no association with gastroschisis.
bullet-2318947 Decongestants, particularly pseudoephedrine and phenylpropanolamine, more than doubled the risk. (Both are blood vessel constrictors.)
bullet-2318947 The extra risk found with various medications was not due to the mother’s reasons for taking them. Neither illness nor fever was associated with gastroschisis. ref_book-8148512 pdf_logo-9894773

SOLVENTS AND DYES USED IN HOBBIES MAY PLAY A ROLE

bullet-2318947 Mothers were asked about work activities as well as hobbies during pregnancy. An industrial hygienist evaluated exposures that might be associated with each occupation/hobby.
bullet-2318947 Several hobbies—ranging from automechanics to weaving—increased risk for gastroschisis. All but 2 involved the use of solvents or colorants (dyes). ref_book-8148512 pdf_logo-9894773
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