Discoveries and Data: Exposures and Risk Factors

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title_ef_drugs-4091983

SUBSTANCE ABUSE RAISES RISK FOR GASTROSCHISIS

Reduced blood supply to the developing abdominal wall is thought to cause gastroschisis, a life-threatening condition where the intestines protrude from a hole near the umbilical cord.

bullet-2941549 Using recreational drugs before or early
in pregnancy increased the risk for gastroschisis. A higher risk was seen if the mother uses more than one type of drug, and if both parents are drug users.
bullet-2941549 Cocaine-using mothers were more than 4 times as likely to have a baby with gastroschisis.
bullet-2941549 Using marijuana, amphetamines, or alcohol (either daily or binge drinking) raised risk by 2 to 4 times.

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DRUGS DID NOT RAISE NEURAL TUBE DEFECT RISK

bullet-2941549 Using cocaine, amphetamines/speed or marijuana before conception or in early pregnancy was associated with reduced risk for neural tube defects.
bullet-2941549 This may be due to reporting differences (mothers of affected infants may be reluctant to admit to drug use), higher miscarriage rate among drug-exposed pregnancies or some other bias.
bullet-2941549 Father’s drug use didn’t increase risk.

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